My purpose in this paper is to show that the transcendental approach, first formulated by Kant, and then elaborated by generations of neo-Kantian thinkers and phenomenologists, provides Buddhism in its highest intellectual achievement with a natural philosophy of science. I take this highest achievement to be the Madhyamaka dialectic and soteriology,{1} which was developed in India from the second century C.E. to the seventh century C.E. by masters such as Nāgārjuna, Āryadeva, and Candrakīrti. Relevance: This is an anti-realist interpretation of quantum mechanics related to the work of Francisco Varela.