Synaptic communication, nonsynaptic diffusion neurotransmission and glial activity each update the morphology of the other two. These interactions lead to an endogenous structure of causal entailment. It has internal ambiguities rendering it incomputable. The entailed effects are bizarre. These include abduction of novelty in response to conflicting cues, a resolution of the seeming conflict between freewill and determinism, and anticipatory behavior. Such inherent ambiguity of the causal entailment structure does not preclude the implementation of brain-like activities artificially. Although an algorithm is incapable of neuromimetically reproducing self-referential character of the brain, there is a currently-feasible strategy for wiring a “human in the loop” to use the cognitive powers of anticipation and unconscious integration to provide dramatic improvement in the operation of large engineered systems.