Key word "intracranial eeg"
Le Van Quyen M., Martinerie J., Navarro V., Boon P., D\Havé M., Adam C., Renault B., Varela F. J. & Baulac M. (2001) Anticipation of epileptic seizures from standard EEG recordings. The Lancet, 357(9251): 183–188.
Le Van Quyen M., Martinerie J., Navarro V., Boon P., D'Havé M., Adam C., Renault B., Varela F. J. & Baulac M.
(
2001)
Anticipation of epileptic seizures from standard EEG recordings.
The Lancet, 357(9251): 183–188.
Background: New methods derived from non-linear analysis of intracranial recordings permit the anticipation of an epileptic seizure several minutes before the seizure. Nevertheless, anticipation of seizures based on standard scalp- electroencephalographical (EEG) signals has not been reported yet. The accessibility to preictal changes from standard EEGs is essential for expanding the clinical applicability of these methods. Methods: We analysed 26 scalp-EEG/video recordings, from 60 min before a seizure, in 23 patients with temporal-lobe epilepsy. For five patients, simultaneous scalp and intracranial EEG recordings were assessed. Long-term changes before seizure onset were identified by a measure of non-linear similarity, which is very robust in spite of large artifacts and runs in real-time. Findings: In 25 of 26 recordings, measurement of non-linear changes in EEG signals allowed the anticipation of a seizure several minutes before it occurred (mean 7 min). These preictal changes in the scalp EEG correspond well with concurrent changes in depth recordings. Interpretation: Scalp-EEG recordings retain sufficient dynamical information which can be used for the analysis of preictal changes leading to seizures. Seizure anticipation strategies in real-time can now be envisaged for diverse clinical applications, such as devices for patient warning, for efficacy of ictal-single photon emission computed tomography procedures, and eventual treatment interventions for preventing seizures.
Le Van Quyen M., Martinerie J., Navarro V., Boon P., D’Hiv M., Varela F. J. & Baulac M. (2001) Anticipation of epileptic seizures from standard EEG recording. The Lancet 357: 183–188.
Le Van Quyen M., Martinerie J., Navarro V., Boon P., D’Hiv M., Varela F. J. & Baulac M.
(
2001)
Anticipation of epileptic seizures from standard EEG recording.
The Lancet 357: 183–188.
Background: New methods derived from non-linear analysis of intracranial recordings permit the anticipation of an epileptic seizure several minutes before the seizure. Nevertheless, anticipation of seizures based on standard scalpelectroencephalographical (EEG) signals has not been reported yet. The accessibility to preictal changes from standard EEGs is essential for expanding the clinical applicability of these methods. Methods: We analysed 26 scalp-EEG/video recordings, from 60 min before a seizure, in 23 patients with temporal-lobe epilepsy. For five patients, simultaneous scalp and intracranial EEG recordings were assessed. Long-term changes before seizure onset were identified by a measure of non-linear similarity, which is very robust in spite of large artifacts and runs in real-time. Findings: In 25 of 26 recordings, measurement of non-linear changes in EEG signals allowed the anticipation of a seizure several minutes before it occurred (mean 7 min). These preictal changes in the scalp EEG correspond well with concurrent changes in depth recordings. Interpretation: Scalp-EEG recordings retain sufficient dynamical information which can be used for the analysis of preictal changes leading to seizures. Seizure anticipation strategies in real-time can now be envisaged for diverse clinical applications, such as devices for patient warning, for efficacy of ictal-single photon emission computed tomography procedures, and eventual treatment interventions for preventing seizures.
Le van Quyen M., Martinerie. J., Adam C. & Varela F. J. (1999) Nonlinear analyses of interictal EEG map the brain interdependences in human focal epilepsy. Physica D 127: 250–266.
Le van Quyen M., Martinerie. J., Adam C. & Varela F. J.
(
1999)
Nonlinear analyses of interictal EEG map the brain interdependences in human focal epilepsy.
Physica D 127: 250–266.
The degree of interdependence between intracranial electroencephalographic (EEG) channels was investigated in epileptic patients with temporal lobe seizures during interictal (between seizures) periods.With a novelmethod to characterize nonlinear cross-predictability, that is, the predictability of one channel using another channel as data base, we demonstrated here a possibility to extract information on the spatio-temporal organization of interactions between multichannel recording sites. This method determines whether two channels contain common activity, and often, whether one channel contains activity induced by the activity of the other channel. In particular, the technique and the comparison with surrogate data demonstrated that transient large-scale nonlinear entrainments by the epileptogenic region can be identified, this with or without epileptic activity. Furthermore, these recurrent activities related with the epileptic foci occurred in well-defined spatio-temporal patterns. This suggests that the epileptogenic region can exhibit very subtle influences on other brain regions during an interictal period and raises the possibility that the cross-predictability analysis of interictal data may be used as a significant aid in locating epileptogenic foci.
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