Publication 2039

Le van Quyen M., Adam C., Martinerie J., Baulac M., Clemenceau S. & Varela F. J. (2000) Spatio-temporal characterizations of non-linear changes in intracranial activities prior to human temporal lobe seizures. European Journal of Neuroscience 12(6): 2124–2134.
Recent studies have shown that non-linear analysis of intracranial activities can detect a ‘pre-ictal phase’ preceding the epileptic seizure. Nevertheless, the dynamical nature of the underlying neuronal process and the spatial extension of this pre-ictal phase still remain unknown. In this paper, we address these aspects using a new non-linear measure of dynamic similarity between different parts of intracranial recordings of nine patients with medial temporal lobe epilepsy recorded during transitions to seizure. Our results confirm that non-linear changes in neuronal dynamics allow, in most cases (16 out of 17), a seizure anticipation several minutes in advance. Furthermore, we show that the spatial distribution of pre-ictal changes often involves an extended network projecting beyond the limits of the epileptogenic region. Finally, the pre-ictal phase could frequently (13 out of 17) be characterized with a marked shift toward slower frequencies in upper delta or theta frequency range.
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