Coutinho A., Andersson A., Sunsblad A., Lundkvist I., Holmberg D., Arala-Chaves M., Stewart J. & Varela F. J. (1990) The dynamics of immune networks. In: Osterhaus A. & Uytdehaag F. (eds.) Idiotype networks in biology and medicine. Excerpta Medica, Amsterdam: 59–63. https://cepa.info/1950
We monitored in normal adult BALB/c mice the serum concentrations of four natural IgM antibodies, two of which show idiotypic complementarity in in vitro assays. In each individual, serum concentration of all four idiotypes were found to fluctuate in complex dynamical patterns with low correlation. The spectral power of some such patterns was found to be compatible with the existence of a chaotic regime. Groups of normal adult mice were injected intravenously with low (10 ng) or moderate (10 micrograms) doses of either of the two complementary idiotypes in saline. This treatment resulted in a pronounced inhibition of the fluctuation in the serum concentration of both complementary idiotypes for periods up to 3 months. Such compensations were not detected for the two unrelated natural idiotypes and were specifically induced, for they did not occur following the injection of unrelated antibodies. These results indicate the functional operation of an idiotypic network among natural antibodies.
Varela F. J., Anderssen A., Dietrich G., Sundblad A., Holmberg D., Kazatchkine M. & Coutinho A. (1991) The population dynamics of natural antibodies in normal and autoimmune individuals. PNAS 88(13): 5917–5921. https://cepa.info/2072
We have measured the quantities of naturally occurring autoantibodies in the serum of normal, unmanipulated individuals. These changes over time following broad-band complex dynamical patterns that are similar in mouse and man. The patterns more likely reflect the network architecture of the natural antibody repertoire, regulating the activation and decay of individual clones. The temporal changes of both disease-specific and nonspecific autoantibodies are consistently modified in autoimmune individuals.