Publication 845

The deterministic component of the structure of the genetic code, derived from tRNA dimerization as proposed by the self-referential model, is described. Anticodon triplets form well defined modules of dimers that are sites for hosting the amino acid guests. The amino acids are the non-deterministic component, selected evolutionarily at the accomplishment of functions in the nucleoprotein ensembles and coevolving with metabolic pathways. The concomitance of the deterministic and the evolutionary components results in regionalization of the attributions in the matrix of encoded correspondences. The regionalized structure is what explains the error-minimizing property of the code structure. Relevance: Our utilization of the notion of self-reference may be relevant for the discussions on autopoiesis. Our model utilizes self-reference as the original and foundational attribute but compartmentalization is considered a derived function in the construction of the biomolecular machinery. The genetic code also reaches integration through the action of protein-protein interactions, between synthetases. Functional closure is reached when the punctuation subsystem is developed, but also in dependence on complex participation of other genes.